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GLP-1 Medications
How GLP-1 and GLP-1/GIP medications work, how to take them correctly, dosing schedules, contraindications, FDA approvals, and important safety guidance.


Ozempic® Sulfur Burps, Gas, and Bloating: Why GLP-1 Medications Cause the “Food-Stuck” Feeling
Experiencing sulfur burps or a "stuck" feeling on Ozempic? Dr. Joshua Silva, MD explains the science of delayed gastric emptying and offers 6 actionable tips to reduce gas and bloating.
Joshua Silva, MD
Jan 268 min read


What Is Retatrutide—and Is It More Effective Than Semaglutide or Tirzepatide for Weight Loss?
Retatrutide is an investigational weight-loss medication often described as a “GLP-3.” This article explains what it is, how it works, how it compares to semaglutide and tirzepatide, safety considerations, FDA status, and whether patients should wait or start treatment now.
Joshua Silva, MD
Jan 87 min read


Who Shouldn’t Take GLP-1 or GLP-1/GIP Weight Loss Medications? Semaglutide (Ozempic®, Wegovy®) and Tirzepatide (Mounjaro®, Zepbound®) Safety Explained
A physician-written guide explaining who should avoid or use caution with GLP-1 and GLP-1/GIP weight-loss medications like semaglutide and tirzepatide.
Joshua Silva, MD
Dec 29, 20257 min read


GLP-1 (semaglutide or tirzepatide) Therapy in Older Adults: Balancing Benefit & Risk Beyond Age 65
Older adults enjoying the benefits of weight loss and eating healthy while using GLP-1 medications (semaglutide or tirzepatide) for safe weight loss, heart health, and muscle and bone support.
Joshua Silva, MD
Dec 12, 20255 min read


GLP-1, GIP & Inflammation: What These Medications Really Do — and What They Don’t
What GLP-1/GIP medications really do for inflammation — and what they don’t. A clear, evidence-based guide for patients.
Joshua Silva, MD
Dec 5, 20257 min read


Semaglutide and Tirzepatide for PCOS: Evidence-Based Benefits for Hormones, Insulin Resistance, and Weight
Semaglutide and tirzepatide can significantly improve insulin resistance, hormones, and weight in women with PCOS. Learn what clinical research shows—and whether these medications may be right for you.
Joshua Silva, MD
Nov 23, 20256 min read


Zepbound (Tirzepatide) vs. Wegovy (Semaglutide): Which Weight-Loss Medication Is Right for You?
If you’re comparing Zepbound (tirzepatide, GLP-1/GIP) vs. Wegovy (semaglutide, GLP-1) for weight loss, you’re not alone. These two medications are the most effective weight-loss injections available today — and both can help you lose significant weight safely under physician supervision. This guide breaks down how each medication works, how they differ, which one produces more weight loss, what side effects to expect, and how to choose the option that fits your goals, bud
Joshua Silva, MD
Nov 19, 20255 min read


Wegovy® Tablets (Oral Semaglutide) 25 mg: FDA Approval, Dosing, and What to Know
Oral semaglutide (Wegovy® tablets) is now FDA-approved for chronic weight management. This once-daily 25 mg pill uses the same active ingredient as injectable Wegovy®, offering a needle-free option for patients who can’t tolerate injections or prefer a daily tablet. Learn how it works, how it compares to Wegovy® injections, and what this new approval means for access, dosing, and real-world weight-loss results.
Joshua Silva, MD
Oct 30, 20255 min read


Wegovy (semaglutide) & MASH Approval
Wegovy (semaglutide) is now FDA-approved for MASH with fibrosis (F2–F3) in adults. See what this means for treatment, eligibility, and weight management.
Joshua Silva, MD
Oct 17, 20253 min read


Compounded Semaglutide & Tirzepatide in 2026: FDA Rules, Safety Risks, and How to Choose a Legitimate Pharmacy
Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As of 2026, compounded semaglutide and tirzepatide are no longer broadly permitted in the United States. Following resolution of nationwide shortages, the FDA ended its temporary enforcement discretion, meaning these medications may now only be compounded under limited, legally defined circumstances .¹–³ On February 21, 2025 , the U.S. Food and Drug Administration formally declared the
Joshua Silva, MD
Oct 3, 20255 min read


Wegovy (Semaglutide) Cardiovascular Risk Reduction
Wegovy (semaglutide) is FDA-approved to reduce major heart risks in adults with obesity/overweight and cardiovascular disease. Learn what it means and who qualifies.
Joshua Silva, MD
Sep 26, 20253 min read
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