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Retatrutide is an investigational weight-loss medication often described as a “GLP-3.” This article explains what it is, how it works, how it compares to semaglutide and tirzepatide, safety considerations, FDA status, and whether patients should wait or start treatment now.

A physician-written guide explaining who should avoid or use caution with GLP-1 and GLP-1/GIP weight-loss medications like semaglutide and tirzepatide.

How fast do GLP-1 medications work? This physician-written guide explains what to expect when starting semaglutide or tirzepatide — including early weight-loss patterns, the dose-escalation delay, and real results from clinical trials. Learn why dose matters and how these medications follow a predictable weight-loss curve over 12–18 months.

Weight loss often slows or plateaus on semaglutide and tirzepatide. Learn why this happens, what clinical trials show, and evidence-based options when progress slows.