If you’re comparing Zepbound (tirzepatide, GLP-1/GIP) vs. Wegovy (semaglutide, GLP-1) for weight loss, you’re not alone. These two medications are the most effective weight-loss injections available today — and both can help you lose significant weight safely under physician supervision. This guide breaks down how each medication works, how they differ, which one produces more weight loss, what side effects to expect, and how to choose the option that fits your goals, budget,