Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Yes—early research shows GLP-1 medications like semaglutide and tirzepatide may reduce cravings and reward-driven behaviors related to alcohol and other substances. However, they are not FDA-approved for addiction, and evidence varies by substance and study type.¹ How GLP-1 Medications Affect Addiction (Brain and Dopamine Explained) GLP-1 medications may influence addiction by modulating r