Can you take semaglutide or tirzepatide if you’re on insulin or metformin? This evidence-based guide explains which diabetes medications are compatible, what the ADA recommends, and how GLP-1/GIP therapy affects blood sugar and A1C.

Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Last clinically updated: December 2025 Carrying extra weight affects far more than appearance — it shapes how nearly every system in your body functions. From your heart and hormones to your energy, sleep, and long-term health, the impact is often silent until symptoms appear. This physician-written guide breaks down what the science actually shows about the risks of excess weight — and t