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TIRZEPATIDE

“Tirzepatide at all doses was noninferior and superior to semaglutide. Reductions in body weight were greater with tirzepatide than with semaglutide.” 

 

New England Journal of Medicine, Aug 2021

Affordable tirzepatide (Mounjaro)  inections for weight loss in St George, Utah.
Affordable tirzepatide (Mounjaro)  inections for weight loss in St George, Utah.

Clinically proven to lose up to 21% of your body weight with diet and exercise. 

FDA Approved treatment for obesity

What is tirzepatide?

Tirzepatide is a medication approved by the FDA for the treatment of obesity in November 2023.

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How does tirzepatide work?

Tirzepatide is a double agonist.  The molecular structure of tirzepatide allows it to act on GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, allowing it to address obesity through two physiologic processes.  It is thought that this is the reason it is more effective than semaglutide.

Tirzepatide acts on the pancreas to improve insulin secretion and suppress glucagon.  It works on the stomach to delay gastric emptying.  It also acts on the brain to suppress appetite and control cravings. 

1) Rosenstock, J., Wysham, C., Frías, J. P., Kaneko, S., Lee, C. J., Landó, L. F., ... & Thieu, V. T. (2021). Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial. The Lancet, 398(10295), 143-155. 2) Shaefer Jr, C. F., Kushner, P., & Aguilar, R. (2015). User’s guide to mechanism of action and clinical use of GLP-1 receptor agonists. Postgraduate Medicine, 127(8), 818-826.

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How much weight can I lose with tirzepatide?

Tirzepatide has been clinically shown to reduce weight by up to 21%.  

1) Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & Stefanski, A. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216.

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What else can tirzepatide do for my health?

Tirzepatide is being studied for its protective effects on the heart including a decrease of cardiovascular death, myocardial infarction, stroke, hospitalized unstable angina.  A major study is being completed in 2024 which should shed more light on these additional benefits.

1) Sattar N, McGuire DK, Pavo I, et al. Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis.Nat Med. 2022;28(3):591-598. 2) Patoulias D, Caprio M, Stoian AP, Rizzo M. Tirzepatide and glucagon-like peptide-1 receptor agonists: safety always comes first!Expert Opin Drug Saf. 2023;22(9):763-765.

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What are the side effects of tirzepatide?

Side effects of tirzepatide are dose-related meaning the higher the dose, the increased likelihood and severity of side effects.  These include mild-to-moderate nausea, diarrhea, vomiting, and constipation were the most common tirzepatide adverse effects.  

 

Starting at a low dose and acclimating your body to the medication has been shown to alleviate many of these side effects. 

Tirzepatide has been linked to medullary thyroid carcinoma (MTC) in humans and is contraindicated in patients with a personal or family history of MTC or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2). Symptoms that may indicate a thyroid tumor include a mass in the neck, difficulty or painful swallowing, labored breathing, and persistent hoarseness.

 

Tirzepatide can cause an increase in heart rate which tends to go away after 24 weeks on the medication.  

1) Jastreboff AM, Kaplan LM, Frías JP, et al. Triple-hormone-receptor agonist retatrutide for obesity: a phase 2 trial.N Engl J Med. 2023;389(6):514-526. 2) Rosenstock J, Frias J, Jastreboff AM, et al. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.Lancet. 2023;402(10401):529-544. 3) Tan B, Pan XH, Chew HSJ, et al. Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis.Int J Obes (Lond). 2023;47(8):677-685.

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How do I take tirzepatide?

Tirzepatide is administered as an injection given once a week.

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How much does tirzepatide cost?

The cost of Tirzepatide is based on the monthly dose you require. 

Tirzepatide Price.jpg

*Price includes office visit, medication, and supplies

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Does tirzepatide result in loss of muscle mass?

1) Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & Stefanski, A. (2022). Tirzepatide once weekly for the treatment of obesity. New England Journal of Medicine, 387(3), 205-216.

Tirzepatide behaves similar to semaglutide with regard to loss of muscle and fat tissue.   Studies indicate that tirzepatide has a slightly more favorable ratio of lean mass loss to fat mass loss.  

 

Learn more about GLP-1 receptor agonists (semaglutide and tirzepatide) and their effect on muscle and fat loss.

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