Tirzepatide: An Alternative or a Complement to TRT
Tirzepatide should NOT be seen as dismissing TRT. Rather, it offers an alternative for overweight men—especially those whose low testosterone is tied to excess weight and metabolism.
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By reducing excess fat, tirzepatide lowers the conversion of natural testosterone into estrogen and helps restore the body’s ability to maintain healthy testosterone levels.
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For men already on TRT, this makes tirzepatide a powerful complement used in conjunction with TRT, supporting weight loss and enhancing hormonal balance.
Book a Free Semaglutide or Tirzepatide Weight Loss Consult
Please choose your preferred clinic (St. George or Cedar City) and whether you’d like an in-person or virtual appointment, or schedule your weekly in-clinic injection.
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State licensing requires Utah residency for virtual (telehealth) appointments. If you live in Utah—even part-time—you’re eligible for telehealth. Patients outside Utah, including Mesquite or Las Vegas, NV, are always welcome to book an in-person visits to establish care.
Tirzepatide and Testosterone Levels
What the Study Showed
Backed by Clinical Evidence
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A 2025 clinical pilot study (La Vignera et al., Reproductive Biology and Endocrinology) compared overweight men treated with tirzepatide to those receiving testosterone therapy (TRT). Over 8 weeks, the study tracked changes in weight, waist size, and hormone levels.
The results confirmed a clear link between excess body fat and hormonal imbalance in men.
Group A – Tirzepatide + Lifestyle
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Medication & Dose: Weekly tirzepatide injections (2.5 mg in the first month, increased to 5 mg the following month).
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Results after 8 weeks:
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Body weight: ↓ 8.1%
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Waist circumference: ↓ 8.2%
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Testosterone: ↑ 128.5% (more than doubled)
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Estrogen: ↓ 60.8%
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Group B – Testosterone (TRT) + Lifestyle
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Medication Used: Transdermal testosterone gel (AndroGel® 1.62%)
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Starting Dose: 23 mg/day, applied to the upper arms/shoulders for the first 14 days.
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Adjustment: After 14 days, the dose was titrated according to the manufacturer’s guidelines (FDA label) to bring blood testosterone into the normal male range (up to a max of 81 mg/day).
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Results after 8 weeks:
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Body weight: ↓ 3.0%
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Waist circumference: ↓ 1.8%
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Testosterone: ↑ 46.2%
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Estrogen: ↑ 21.2%
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📊 Study Results Summary Table
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Source: La Vignera S, et al. Reproductive Biology and Endocrinology, 2025.
What Do These Findings Mean?
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The exciting part of this study isn’t that tirzepatide will help you achieve higher testosterone levels than TRT. If you increase the dose of TRT enough, your testosterone will rise indefinitely.
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What makes these findings important is that they highlight how weight and metabolism affect hormone imbalance in men:
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1. The Effect of Fat (Adipose Tissue) on Testosterone Levels
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Excess body fat—especially abdominal fat—acts almost like a hormonal organ of its own. Fat tissue produces an enzyme called aromatase, which converts testosterone into estrogen. The more fat you carry, the more aromatization occurs, which lowers available testosterone and raises estrogen. International Journal of Endocrinology (2012), Journal of Nutrition, Health & Aging (2016)
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2. Why Supplemental Testosterone (TRT) Alone May Increase Estrogen
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When men with excess fat use TRT, testosterone levels do rise—but a portion of that testosterone is rapidly converted to estrogen by aromatase in fat tissue. This can lead to unwanted side effects of higher estrogen in men, such as fluid retention, breast tissue enlargement (gynecomastia), and decreased testicular size. The study showed exactly this: TRT raised testosterone but also increased estrogen by ~21%. Journal of Clinical Endocrinology & Metabolism (2010)
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3. Why Losing Fat Improves Male Hormone Levels
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Tirzepatide led to significant fat and waist reduction. Less fat means less aromatization, which means more testosterone stays as testosterone and less is converted to estrogen. The result is a natural rise in testosterone and a fall in estrogen—a healthier hormonal balance without simply pushing testosterone levels artificially higher.
Whether you’re already using TRT or exploring other options, Potere Health MD can help you achieve better weight loss and healthier hormone balance—for as low as $87 per month. Schedule your free consultation today.
Meet Tirzepatide
Here's How the Cost Breaks Down
What is Tirzepatide?
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Tirzepatide is a once-weekly injectable medication used to support weight loss. It mimics two natural hormones in your body — GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), giving it a dual mechanism of action. This serves to:
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Reduce hunger and cravings
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Slow digestion so you feel full longer
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Improve insulin sensitivity and help regulate blood sugar
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Work together to enhance your body’s natural ability to lose weight
Expected Weight Loss with Tirzepatide
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Clinical trials show that weight loss with tirzepatide is dose dependent — higher doses generally lead to greater weight reduction. On average, participants lost about 15% of their body weight at 5 mg, 19.5% at 10 mg, and 21% at 15 mg.
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The study evaluating tirzepatide in combination with testosterone replacement therapy focused specifically on the 5 mg dose.
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Source: New England Journal of Medicine, 2022 – Tirzepatide SURMOUNT-1 Trial (Jastreboff et al.)
How Much Does Tirzepatide Cost
30 mg vial = $340
60 mg vial = $465
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How Long Will a Vial Last?
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The length of time a vial will last depends on your prescribed weekly dose and the vial size you purchase. Check the table below to see how long one vial covers at different dosing levels — we’ve also included the estimated monthly cost for each dose to help you plan ahead.
Benefits Beyond Weight Loss & Hormonal Balance
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Tirzepatide can improve your overall health in several important ways:
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Better blood sugar control – helps people with type 2 diabetes lower A1C and improve insulin sensitivity (New England Journal of Medicine, 2021).
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Healthier cholesterol and triglycerides – supports better heart and vascular health (Diabetes, Obesity and Metabolism, 2023).
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Lower blood pressure – reduces strain on your heart and blood vessels (Heart, 2024).
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Improved liver health – shown to help patients with fatty liver disease (New England Journal of Medicine, 2024).
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Better sleep – reduces the severity of obstructive sleep apnea (New England Journal of Medicine, 2024).
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Kidney protection – slows down kidney damage and helps maintain kidney function (Lancet Diabetes & Endocrinology, 2022).
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Heart failure support – in people with preserved ejection fraction, improves symptoms and lowers the risk of hospitalization (New England Journal of Medicine, 2025).
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Heart health (Major Adverse Cardiovascular Events – MACE) – early evidence suggests a possible cardiovascular benefit, with a large dedicated outcomes trial underway to confirm this (JAMA Network Open, 2024).
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Inflammation – tirzepatide has been shown to reduce systemic inflammation (ScienceDirect, 2024)
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Dementia / Neuroprotection – emerging data suggest tirzepatide may help protect the brain and lower dementia risk (JAMA 2025)
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Taken together, these benefits show that tirzepatide is more than a weight-loss medication—it also helps protect your metabolism, heart, liver, kidneys, and sleep health.
Meet Semaglutide
Here's How the Cost Breaks Down
What is Semaglutide?
Semaglutide is a once-weekly injectable medication used to support weight loss. It mimics one of your body’s natural hormones — GLP-1 (glucagon-like peptide-1) — to help you lose weight safely and effectively. This works by:
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Reducing hunger and cravings
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Slowing digestion so you feel full longer
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Improving insulin sensitivity and helping regulate blood sugar​
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By acting on these pathways, semaglutide supports steady, sustainable weight loss and long-term metabolic health.​
Expected Weight Loss with Semaglutide
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Clinical trials show that weight loss with semaglutide is dose dependent — higher doses generally lead to greater weight reduction. On average, participants lost about 15% of their body weight at 2.4 mg.
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Source: New England Journal of Medicine, 2021 – Semaglutide STEP-1 Trial (Wilding et al.)
How Much Does Semalgutide Cost
5 mg vial = $200
10 mg vial = $275
20 mg vial = $420
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How Long Will a Vial Last?
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The length of time a vial will last depends on your prescribed weekly dose. Check the table below to see how long one vial covers at different dosing levels — we’ve also included the estimated monthly cost for each dose to help you plan ahead.
How It Works
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Why Choose POTERE HEALTH MD
Medically Supervised Weight Loss
Supervised by a Physician Who Puts Safety First
Dr. Joshua Silva, MD established Potere Health MD to offer a safer, more affordable option for weight loss—bridging the gap between overpriced clinics and low-cost internet sites that lack proper medical oversight.
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Your weight loss journey is personally overseen by Dr. Silva to ensure individualized dosing, assistance with any side effects, and personalized guidance to achieve maximum–yet safe–weight loss.
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