top of page

SEMAGLUTIDE

"Semaglutide essentially doubled the weight loss observed with existing obesity medications, ushering in the era of second-generation anti-obesity medications.”

W Timothy Garvey, MD. Endocrine Practice, February  2022.

Affordable semaglutide inections for weight loss in St George, Utah.
Affordable semaglutide inections for weight loss in St George, Utah.

Clinically proven to lose 15% of your body weight with diet and exercise. 

FDA Approved treatment for obesity

We offer home delivery

Starts at $120 a month and includes medication and visit with the medical doctor.

What is semaglutide?

Semaglutide is a glucagon-like petide-1 (GLP-1) analog that acts on GLP-1 receptors.  It was cleared by the FDA for weight loss in June 2021. 

It is also known as Ozempic, Wegovy, Rhybelsus.

Collapsible text is great for longer section titles and descriptions. It gives people access to all the info they need, while keeping your layout clean. Link your text to anything, or set your text box to expand on click. Write your text here...

Anchor 1

How does semaglutide work?

Semaglutide acts on the pancreas to improve insulin secretion and suppress glucagon.  It works on the stomach to delay gastric emptying. It also acts on the brain to suppress appetite and control cravings. 

1) Shaefer Jr, C. F., Kushner, P., & Aguilar, R. (2015). User’s guide to mechanism of action and clinical use of GLP-1 receptor agonists. Postgraduate Medicine, 127(8), 818-826.

Anchor 2

How much weight can I lose with semaglutide?

Semaglutide has been clinically shown to reduce weight by up to 15%.  

1) Garvey WT. Is obesity or adiposity-based chronic disease curable: the set point theory, the environment, and second-generation medications. Endocr Pract. 2022;28(2):214-222.

Anchor 3

How do I take semaglutide?

Semaglutide for weight loss is given as a once-a-week injection.

Collapsible text is great for longer section titles and descriptions. It gives people access to all the info they need, while keeping your layout clean. Link your text to anything, or set your text box to expand on click. Write your text here...

Anchor 4

What are the side effects of semaglutide?

1) Smits, M. M., & Van Raalte, D. H. (2021). Safety of semaglutide. Frontiers in endocrinology, 12, 645563. 2) Bays HE, Burridge K, Richards J, Fitch A. Obesity Pillars roundtable: excessive weight reduction with highly effective anti-obesity medications (heAOMs). Obes Pillars. 2022;4:100039.

The most common side effects of semaglutide include mild-to-moderate nausea, diarrhea, vomiting, and constipation. These side effects are dose-related meaning the higher the dose, the increased likelihood and severity of side effects.  

 

You can alleviate many of these side effects by starting at a low dose and acclimating your body to the medication. 

 

Semaglutide has been linked to medullary thyroid carcinoma (MTC) in humans and is contraindicated in patients with a personal or family history of MTC or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2). Symptoms that may indicate a thyroid tumor include a mass in the neck, difficulty or painful swallowing, labored breathing, and persistent hoarseness.

Anchor 5

How much does semaglutide cost?

The cost of Semaglutide depends on the dose you are taking.  Monthly cost starts at $120 and plateaus at $300 (see below).  

Semaglutide Price.jpg

*Price includes office visit, medication, and supplies

Special

3 months of semaglutide (weeks 1-12) for 

$365

Anchor 6

Semaglutide and muscle mass.

A Canadian physician, Peter Attia, claimed on an Instagram post that "almost every patient we put on this drug [semaglutide] has lost muscle mass at a rate that alarms me."

So what does the medical literature say about diet and weight loss as it pertains to muscle mass?

1) It is well established that up to 30% of total weight loss in obese individuals will be from lean body mass.1 The amount of lean body mass lost will be higher in short term and crash diets.2. Normal weight individuals will lose upwards of 35% of lean body mass during weight loss.3

2) In general, "compared with persons with normal weight, those with obesity have more muscle mass but poor muscle quality; [additionally,] diet-induced weight loss reduces muscle mass without adversely affecting muscle strength"4

 

 3) The following quotations come from four different studies evaluating the effect of semaglutide on lean body mass during weight loss.  All four concluded that semaglutide did in fact result in loss of lean body mass (as would be expected), but overall it improved the ratio of lean body mass to fat mass.

a. "In adults with overweight/obesity, once-weekly semaglutide 2.4 mg was associated with reduced total fat mass and regional visceral fat mass, and a relatively increased proportion of lean body mass. Greater weight loss was associated with greater improvement in body composition (total lean body mass to total fat mass ratio).”5

b. “Visceral Adipose Tissue (VAT) decreased, while Fat Free Mass and Skeletal Muscle Mass (SMM) were preserved during therapy, resulting in a beneficial increase in the SMM/VAT ratio.  Finally, an overall improvement in body fluid distribution was observed.”6

c.  "In a real-world setting, semaglutide can reduce the weight and fat of obese patients while effectively maintaining muscle mass and muscle strength."7

d. “The 24-week treatment with oral semaglutide ameliorated glycemic control with reduction of body fat but not muscle mass in Japanese patients with type 2 diabetes.”8

4) Semaglutide has been shown to reduce the incidence of death from cardiovascular causes, nonfatal myocardial infarction, and nonfatal stroke in both diabetic and non-diabetic patients.9  Therefore, the risk of loss of muscle mass must be weighed against the benefit of improved cardiovascular and cerebrovascular health. 

5) "Both endurance- and resistance-type exercise help preserve muscle mass during weight loss, and resistance-type exercise also improves muscle strength."10

Conclusion:  You can expect to lose both lean body mass and fat mass during a diet assisted with semaglutide.  According to peer reviewed medical research, you can expect to see an improvement in your overall ratio of lean body mass to fat mass.  Best practice suggests that you accompany weight loss with some type of endurance or resistance exercise to minimize the effects of the loss of lean body mass during any weight loss program. 

We are pleased to partner with Premier Fit to offer you with exercise and nutritional counseling and classes to assist you in your weight loss goals. 

1) Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med 2011;364:1218–29. 2) Hansen, T. T., Hjorth, M. F., Sandby, K., Andersen, S. V., Astrup, A., Ritz, C., ... & Sjödin, A. (2019). Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet. British Journal of Nutrition, 122(4), 468-479. 3) Bosy-Westphal, A., Kossel, E., Goele, K., Later, W., Hitze, B., Settler, U., ... & Müller, M. J. (2009). Contribution of individual organ mass loss to weight loss–associated decline in resting energy expenditure. The American journal of clinical nutrition, 90(4), 993-1001. 4) Cava E, Yeat NC, Mittendorfer B. Preserving Healthy Muscle during Weight Loss. Adv Nutr. 2017;8(3):511-519. Published 2017 May 15.  5) Wilding JPH, Batterham RL, Calanna S, et al. Impact of Semaglutide on Body Composition in Adults With Overweight or Obesity: Exploratory Analysis of the STEP 1 Study. J Endocr Soc. 2021;5(Suppl 1):A16-A17. Published 2021 May 3. 6) Volpe, S., Lisco, G., Fanelli, M., Racaniello, D., Colaianni, V., Lavarra, V., ... & Piazzolla, G. (2023). Oral semaglutide improves body composition and preserves lean mass in patients with type 2 diabetes: A 26-week prospective real-life study. Frontiers in Endocrinology, 14. 7) Xiang J, Ding XY, Zhang W, Zhang J, Zhang YS, Li ZM, Xia N, Liang YZ. Clinical effectiveness of semaglutide on weight loss, body composition, and muscle strength in Chinese adults. Eur Rev Med Pharmacol Sci. 2023 Oct;27(20):9908-9915. 8) Uchiyama S, Sada Y, Mihara S, Sasaki Y, Sone M, Tanaka Y. Oral Semaglutide Induces Loss of Body Fat Mass Without Affecting Muscle Mass in Patients With Type 2 Diabetes. J Clin Med Res. 2023;15(7):377-383. 9) Lincoff, A. M., Brown-Frandsen, K., Colhoun, H. M., Deanfield, J., Emerson, S. S., Esbjerg, S., ... & Ryan, D. H. (2023). Semaglutide and cardiovascular outcomes in obesity without diabetes. New England Journal of Medicine, 389(24), 2221-2232. 10) Cava E, Yeat NC, Mittendorfer B. Preserving Healthy Muscle during Weight Loss. Adv Nutr. 2017;8(3):511-519. Published 2017 May 15.

Semaglutide Tirzeptide Muscle Mass loss
Anchor 7
bottom of page