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Lovers Embrace
Platelet rich plasma injections (o-shot) to address vaginal dryness, pain during intercourse, stress incontinence, lack of sesxual stimulation in St George Utah.

Platelet Rich Plasma Injections
(PRP)

“Platelet Rich Plasma, “O-Shot” is an in-office treatment that is safe, effective, non-surgical, and non- hormonal option for women having stress incontinence, overactive bladder, lack of lubrication, and sexual dysfunction, such as lack of libido, arousal or dyspareunia.”

 

Dr. Neto, Journal of Women’s Health Care, vol 6, pg 395.

Vaginal Rejuvination

PRP injection for g-spot, clitoral stimulation in St George Utah.

Increased sensation

Greater arousal from clitoral stimulation

The ability to have an orgasm from penetrative sex when previously unable

Stronger and more frequent orgasms


Increased ability to have a vaginal orgasm

Improvement in urinary incontinence

Younger and smoother skin of the vulva

Decreased pain for those experiencing painful sex

Increased natural lubrication

O shot PRP shot injection procedure vaginal rejuvenation
PPR injection (o-shot) administration for vaginal rejuvenation, vaginal dryness.

Stress Urinary Incontinence 

“A significant improvement in stress incontinence symptoms was observed 3 months after treatment [of platelet rich plasma] with a further improvement at 6 months. ... At the 6-month follow-up, 80.0% of women reported to be at least improved. No adverse effects were observed.”

Female Pelvic Medicine & Reconstructive Surgery, November 2021

What is PRP?

1) Dashore, S., Chouhan, K., Nanda, S., & Sharma, A. (2021). Preparation of platelet-rich plasma: National IADVL PRP taskforce recommendations. Indian Dermatology Online Journal, 12(Suppl 1), S12.

PRP is plasma that has been separated from your blood.  Your blood is processed to separate the red blood cells from the plasma.  It is spun again to further concentrate the platelets and growth factors.  This concentrated plasma, rich in platelets and growth factors, up to 5 times more concentrated than the plasma that we originally harvested from your blood.  We use a double spin technique to ensure the highest concentration of platelet rich plasma possible.

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How does PRP work?

1) Boswell S.G., Cole B.J., Sundman E.A., Karas V., Fortier L.A.. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy. 2012;28:429–439. 2) Foster T.E., Puskas B.L., Mandelbaum B.R., Gerhardt M.B., Rodeo S.A.. Platelet-rich plasma: from basic science to clinical applications. Am. J. Sports Med. 2009;37:2259–2272. 3) Pavlovic V, Ciric M, Jovanovic V, Stojanovic P. Platelet Rich Plasma: a short overview of certain bioactive components. Open Med (Wars). 2016 Aug 12;11(1):242-247.

Platelets contain more than 1100 different proteins.  Importantly, they are a storage site for the seven main growth factors found in blood.

 

These include:

  • platelet-derived growth factor (PDGF),

  • transforming growth factor β (TGF-β)

  • vascular endothelial growth factor (VEGF)

  • epidermal growth factor (EGF)

  • insulin-like growth factor (IGF)

  • fibroblast growth factor (FGF).  

 

These growth factors result in cellular regeneration, specifically of blood vessels, nerves, muscles, and collagen necessary for the proper function of the vagina and lower urethra that controls continence.  

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Is PRP safe?

1) John’s Hopkins Medicine. Platelet Rich Plasma Injections. Accessed December 26, 2023. https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/plateletrich-plasma-prp-treatment#:~:text=Although%20the%20equipment%20used%20to,is%20not%20considered%20a%20drug. 2) Sukgen, G., Kaya, A. E., Karagün, E., & Çalışkan, E. (2019). Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction. Turkish journal of obstetrics and gynecology, 16(4), 228. 3) Streit-Ciećkiewicz, D., Kołodyńska, A., Futyma-Gąbka, K., Grzybowska, M. E., Gołacki, J., & Futyma, K. (2022). Platelet Rich Plasma in Gynecology—Discovering Undiscovered. International Journal of Environmental Research and Public Health, 19(9), 5284.

PRP has been experimented with since the 1970’s due to its potential for tissue regrowth and healing.  It is currently widely used in medicine for tendon, ligament, muscle and joint injuries, post-surgical wound healing, osteoarthritis, hair loss, skin rejuvenation, erectile dysfunction, female sexual dysfunction, and stress urinary incontinence.  

 

There is no risk of an adverse reaction to the PRP because it comes from your own plasma.   John Hopkin’s Medicine considers PRP injections “a low-risk procedure and does not usually cause major side effects.”1

 

“To date, no adverse effects have been reported in vaginal applications in the literature.”2

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How does PRP help sexual arousal and orgasm?

1) El‐Sharkawy, H., Kantarci, A., Deady, J., Hasturk, H., Liu, H., Alshahat, M., & Van Dyke, T. E. (2007). Platelet‐rich plasma: growth factors and pro‐and anti‐inflammatory properties. Journal of periodontology, 78(4), 661-669. 2) Sukgen, G., Kaya, A. E., Karagün, E., & Çalışkan, E. (2019). Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction. Turkish journal of obstetrics and gynecology, 16(4), 228.

Platelets release growth factors that result in tissue regeneration, repair, and healing. As blood vessels, nerves, muscles, and collagen repair and heal, they restore both the physiologic function of the vagina such as lubrication and sensitivity.

 

The lower one third of the anterior vaginal wall contains an increased density of nerves and micro-vessels making it more sensitive than other areas and is responsible for much of the physical pleasure associated with sex.  It is postulated that PRP helps restore proper function to this important area of the vagina. 

Patients report a wide range of results from PRP injections including:

  • Increased sensation

  • Greater arousal from clitoral stimulation

  • The ability to have an orgasm from penetrative sex when previously unable

  • Younger and smoother skin of the vulva

  • Stronger and more frequent orgasms

  • Improvement in urinary incontinence

  • Decreased pain for those experiencing painful sex

  • Increased natural lubrication

  • Increased ability to have a vaginal orgasm

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Does PRP really help sexual arousal and orgasm?

1) Runels, C., Melnick, H., Debourbon, E., & Roy, L. (2014). A pilot study of the effect of localized injections of autologous platelet rich plasma (PRP) for the treatment of female sexual dysfunction. J Women’s Health Care, 3(169), 2167-0420. 2) Neto, J. B. (2017). O-Shot: Platelets rich plasma in intimate female treatment. J Women’s Health Care, 6, 395. 3) Sukgen, G., Kaya, A. E., Karagün, E., & Çalışkan, E. (2019). Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction. Turkish journal of obstetrics and gynecology, 16(4), 228. 4) Gaber, M. A., & Shaltout, S. A. (2021). Assessment of autologous platelet-rich plasma as a local therapy for female sexual dysfunction. Menoufia Medical Journal, 34(1), 61.

PRP injections for female sexual dysfunction are relatively new and have not had time for robust clinical evidence to be gathered. The following are excerpts from four different clinical studies regarding the efficacy of PRP injections for female sexual dysfunction.

 

“The preliminary results of this pilot study suggests that specifically placed intravaginal and intraclitoral PRP injections could be an effective method to treat certain types of female sexual dysfunction, especially in the areas of desire, arousal, lubrication and orgasm.”1​

 

“Conclusion: Platelet Rich Plasma, “O-Shot” is an in-office treatment that is safe, effective, non-surgical, and non- hormonal option for women having stress incontinence, overactive bladder, lack of lubrication, and sexual dysfunction, such as lack of libido, arousal or dyspareunia.”2​

 

“As a minimally invasive method, PRP administration to the distal anterior vaginal wall may improve female sexuality with high satisfaction.”3​

 

“There were statistically high significant mean values of desire, arousal, lubrication, orgasm, and satisfaction after treatment (P < 0.001), which is highly significant. PRP is an effective treatment of female sexual dysfunction. It is a minimally invasive procedure with very low side effects.”4

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How does PRP help stress incontinence?

1) Chiang, C. H., & Kuo, H. C. (2022). The efficacy and mid-term durability of urethral sphincter injections of platelet-rich plasma in treatment of female stress urinary incontinence. Frontiers in Pharmacology, 13, 847520. 2) Saraluck, A., Chinthakanan, O., Kijmanawat, A., Aimjirakul, K., Wattanayingcharoenchai, R., & Manonai, J. (2023). Autologous platelet rich plasma (A‐PRP) combined with pelvic floor muscle training for the treatment of female stress urinary incontinence (SUI): A randomized control clinical trial. Neurourology and Urodynamics. 3) Nikolopoulos, K. I., Chrysanthopoulou, E., Pergialiotis, V., Korrou, L. M., Perrea, D. N., Dimitroulis, D., & Doumouchtsis, S. K. (2019). An animal experimental study on pubourethral ligament restoration with platelet rich plasma for the treatment of stress urinary incontinence. Central European Journal of Urology, 72(2), 134.

Stress urinary incontinence (SUI) is caused by weakening of muscles and other tissues that support the urethra (pelvic floor muscles) and the muscles that control the release of urine (urinary sphincter).  It is postulated that the growth factors contained in PRP help restore function to those muscles providing greater control over the lower urethra.   

 

The bulk of treatment for stress incontinence, whether through a vaginal pessary or surgical intervention, is designed to lift and support that lower urethra in order to increase urethral resistance.  This has the effect of providing greater control over leaking urine.  It is postulated that PRP injected in the anterior vagina helps build the connective tissue, including collagen, that naturally lifts and supports that part of the urethra restoring urethral resistance and control.

 

There is also research being done into the effects of PRP on the pubourethral ligament.  The pubourethral ligament is important in stabilizing the normal anatomic position of the lower urethra.  In rats, PRP has been shown to regenerate the function of the pubourethral ligament as measured by before and after leak point pressure of the urethra.  

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Does PRP really help stress incontinence?

1) Athanasiou, S., Kalantzis, C., Zacharakis, D., Kathopoulis, N., Pontikaki, A., & Grigoriadis, T. (2021). The use of platelet-rich plasma as a novel nonsurgical treatment of the female stress urinary incontinence: a prospective pilot study. Urogynecology, 27(11), e668-e672. 2) Long, C. Y., Lin, K. L., Shen, C. R., Ker, C. R., Liu, Y. Y., Loo, Z. X., ... & Lee, Y. C. (2021). A pilot study: Effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence. Scientific reports, 11(1), 1584. 3) Tahoon, A. S., Salem, H. E. D. H., & Mousa, A. A. A. (2022). The Role of Platelet Rich Plasma Injections in Cases of Stress Incontinence. Qeios.

PRP injections for stress incontinence are relatively new and have not had time for robust clinical evidence to be gathered.  The following are excerpts from three different clinical studies regarding the efficacy of PRP injections for stress incontinence.

 

A recent study of PRP injections showed that “a significant improvement in stress incontinence symptoms was observed 3 months after treatment with a further improvement at 6 months. A mean reduction of 50.2% in urine loss was observed in the 1-hour pad test. At the 6-month follow-up, 80.0% of women reported to be at least improved. No adverse effects were observed.”1

“Local injection of platelet rich plasma seems safe with somewhat satisfactory response in treating female SUI both at 1 month and 6 months post treatment” and concluded that “PRP is a considerable treatment option for mild to moderate stress incontinence cases.”2​

“Bivariate analysis revealed a significant incontinence improvement at both 1 month and 3 months post treatment without significant adverse reactions reported. …The result suggested that local injection of autologous platelet rich plasma is a considerable treatment option in treating women with stress urinary incontinence.”3​

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What do the critics say?

1) Dankova, I., Pyrgidis, N., Tishukov, M., Georgiadou, E., Nigdelis, M. P., Solomayer, E. F., ... & Hatzichristou, D. (2023). Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review. Biomedicines, 11(11), 2919.

We believe that individuals should be empowered with all the unbiased evidence for and against any medical treatment so they can make an informed decision regarding their own health. 

The biggest concern, fortunately not a safety concern, is regarding the quality and study design of the existing studies that have looked at PRP for sexual dysfunction and stress urinary incontinence.  This calls into questions the validity of the study results.   

"Despite the promising initial results of PRP injections, the level of current evidence is low due to methodological issues in the available studies. It becomes clear that there is an emerging need for high-quality research examining PRP injections for the treatment of female sexual dysfunction and female stress urinary incontinence."1

We anxiously await the results of further research to gain additional insight into PRP injections for sexual dysfunction and stress urinary incontinence.

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Are there side effects?

1) John’s Hopkins Medicine. Platelet Rich Plasma Injections. Accessed December 26, 2023. https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/plateletrich-plasma-prp-treatment#:~:text=Although%20the%20equipment%20used%20to,is%20not%20considered%20a%20drug. 2) Sukgen, G., Özbosli, E., & Sivaslioglu, A. A. (2023). Platelet rich plasma (PRP) for vaginal tightening: A new approach. Pelviperineology, 42(1).

Side effects are generally limited to mild discomfort, swelling, and redness at the injection site which resolves within a few days.  A few reports of unintentional orgasm have been cited following injections in younger women.  John Hopkin’s Medicine considers PRP injections “a low-risk procedure and does not usually cause major side effects.”

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Do PRP injections hurt?

Mild discomfort can be experienced from the small gauge needle piercing the skin.  Topical anesthesia can be applied to provide more comfort.  Most patients are quite comfortable during the procedure. 

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Are PRP injections FDA approved?

1) John’s Hopkins Medicine. Platelet Rich Plasma Injections. Accessed December 26, 2023. https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/plateletrich-plasma-prp-treatment#:~:text=Although%20the%20equipment%20used%20to,is%20not%20considered%20a%20drug.

“Research for the different applications of PRP is promising and rapidly growing. Although the equipment used to produce PRP and the injections themselves have been cleared by the FDA, this procedure is considered investigational and has not been officially approved by the FDA for most uses. Since PRP is a substance derived from one’s own blood, it is not considered a drug. FDA clearance means that doctors can prescribe and administer PRP if they believe it’s in the best interest of the patient. However, lack of the FDA approval means that PRP treatments may not be covered by insurance.” (John's Hopkins Medicine)

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Is PRP the same as the O-shot?

“O-Shot®” stands for Orchid Shot, a name trademarked and patented in the US by Dr. Charles Runels. It involves harvesting your bodies platelet rich plasma (PRP) and injecting it into specific areas of the vagina and/or clitoris to help with symptoms of stress urinary incontinence and/or improve orgasm and sexual pleasure.  

 

To use and market the name O-Shot®, a physician must pay a fee.  We deeply respect Dr. Runels work and the trademarked name O-Shot®.  We do not pay the fee to use the name O-Shot®, therefore our PRP injection for vaginal rejuvenation is not called an O-Shot®. It is an injection of platelet rich plasma into strategic areas of the vagina and/or clitoris to help with symptoms of stress urinary incontinence and improve orgasm and sexual pleasure.  

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How much does it cost?

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